The 28-year-old, the twin brother of England and Everton defender Michael, represented England up to under-20 level but declared his intention to play for the Republic in February 2019.
The former Manchester United striker qualifies for Ireland through his father and, with Stephen Kenny's side desperate for goals, Keane has now been given his chance.
Kenny said: “Will has had a consistent run of games this year, he's probably having one of his best seasons, and we've managed to see quite a bit of him.
“He links the play well. He leads the line quite well, he has an appreciation of players around him, good weight of pass and good vision, and he can score headed goals and different types of goals.
“He's a good option for us and we're looking forward to getting him in this week and working with him at close quarters."
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