Teams will be allowed to make up to five substitutions in Uefa competitions until the end of the 2020-21 season, reports BBC Sport.
The rule change was proposed by Fifa because of congested fixture schedules caused by the coronavirus pandemic.
In August, the Premier League said it would not adopt the rule change after clubs voted against it.
But Uefa president Aleksander Ceferin said it would be used in European competitions such as the Champions League and Europa League.
It will also be adopted in European national team matches, including the Nations League.
However, a decision has yet to be made on whether the rule will be adopted for next year's rearranged European Championships.
World players' union Fifpro welcomed Uefa's decision.