Pochettino's first match in charge of Tottenham ended in a thrilling 3-3 draw against the Seattle Sounders.
Tottenham took the lead after just 11 minutes, as Lewis Holtby - back at the club following a six-month loan spell with Fulham - latching on to Harry Kane's pinpoint chipped through-ball to cleverly dink a header past Sounders goalkeeper, Stephan Frei.
Michael Dawson conceded a penalty following a heavy challenge which resulted in an expertly applied Penanka penalty from Gonzalo Pineda in the 36th minute.
At half time, Pochettino rang the changes, with no fewer than seven substitutes taking the field, with the Argentine former Southampton manager keen to assess his players at the earliest opportunity.
Subsequently, Spurs were slow to settle, and Cuban powerhouse Oscar Alonso took advantage - lashing home a long-range drive outside the box that left Brad Friedel helpless, caressing the bar on its route to the net.
But Seattle's lead was short lived. Soldado, one of Pochettino's half-time changes, latched on to a through-ball with a sublime touch before being bundled down in the box, resulting in the second spot kick of the match.
Roberto Soldado calmly converted from 12 yards to put Tottenham back on level terms.
Sigi Schmid quickly made changes of his own, and his two substitutes combined to restore Seattle's lead, with Tristan Bowen finishing from close range with little over 10 minutes remaining.
With the game petering out, Spurs still had time to level proceeding, and it came via the third spot kick of the match.
USA's World Cup star, DeAndre Yedlin, was adjudged to handle Iago Falque's pass, and the Spaniard - on loan at Rayo Vallecano last season - applying the finish from the penalty spot to earn Tottenham's, and Pochettino's, share of the spoils in a packed CenturyLink Field.
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