Everton boss Roberto Martinez says Antolin Alcaraz's injury is set to be long-term.
The defender went down in an aerial challenge with Wilfried Bony on 32 minutes and was replaced by Muhamed Besic.
"Antolin has damaged a joint in his shoulder," Martinez told evertonfc.com. "We're going to assess him tonight and tomorrow morning but it seems he's going to be out for a long spell.
"It's a real shame because he had to work really hard to get back to full fitness and perform. He fought hard for his place and was in a good moment. It was an accident and you don't usually get those sort of injuries in football.
"But we'll help him through it and hope he can come back before the second half of the campaign."
