Real midfielder Dani Ceballos and fullback Ferland Mendy both face spells on the sidelines.
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Ceballos is expected to miss the next 6-8 weeks with an ankle sprain, which he suffered during last night's 2-0 win against Real Betis.
Meanwhile, Mendy has pulled out of France's squad this week with a leg strain.
The fullback is expected to be available for Real after the international break.