The Brazil international missed the weekend 2-0 home Premier League loss to rivals Tottenham as a precaution due to an issue.
However, the Spanish coach has now confirmed he will not face Liverpool in the EFL Cup tomorrow, and the former Brighton & Hove Albion attacker could be out of club action until the end of November.
"He has an injury of his thigh and is going to be out for a few weeks. Let's see how many.
"He's not ready for the next games.
"Yeah, for sure we can cope. This is why you build a squad. Some players are important, but this happens."
Joao Pedro's return timeline also indicates he will miss out on Brazil duty once again, after pulling out of the September/October camp with a previous injury.
Brazil take on Japan and Singapore in two friendly games in Kallang on November 14 and 17.