Heading into the sixth and final clash of the series, Xavi Hernandez's team lead the group on 11 points, with Jurgen Klopp's Germany in third place with eight.
Klopp needs a win on home soil to guarantee a place in the 2027 quarter finals after a mixed start to life in the job for the former Liverpool boss.
Germany v Netherlands team news
Klopp sealed a 3-1 win away in Serbia last time out and he could stick with a largely unchanged lineup here with Kai Havertz leading the home attack.
Xavi's charges demolished Greece 7-0 in midweek, but he will be forced into at least one change, with Frenkie de Jong pulling out of the squad due to injury.
Teun Koopmeiners looks set to replace him in the starting XI in Berlin.
Germany v Netherlands predicted lineups
Germany XI: Ter Stegen; Treu, Tah, Thiaw, Mittelstadt; Kimmich, Pavlovic, Gruda; Wirtz, Havertz, Karl.
Netherlands XI: Verbruggen; Dumfries, Van Hecke, Van de Ven, Timber; Koopmeiners, Veerman, Reijnders; Gakpo, Malen, Summerville.
Germany v Netherlands kick off time
Kick off at the Olympiastadion in Berlin is set for 8:45pm local time and 7:45pm in the UK.
Key stat
The sides drew 1-1 in their reverse fixture in September and La Oranje have not beaten their old rivals since 2019.