The former Roma star has continued his criticism of Ronaldo, insisting the Al Nassr striker has always been overrated.
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Cassano says Sergio Aguero, Zlatan Ibrahimovic, Robert Lewandowski and Luis Suarez were all better strikers than Ronaldo.
In response, Ronaldo's sister Elma Aveiro said: "He's a poor man, a clown.
"He was more suited to being a ball boy than a footballer."