With Giorgi Mamardashvili definitely ruled out and Alisson struggling to make the game, Slot said this morning the likelihood would be that third-choice Woodman will start against Palace.
Liverpool go into the game sitting in fifth place on the Premier League table, three points behind fourth place Aston Villa.
Slot said of his keeper options: "Giorgi will definitely not be available and for the upcoming week. Ali is close to a return of play, let's see if tomorrow comes too early yes or no. That leaves Freddie as an option.
"For a reason we signed experienced third goalkeeper. That's why we were happy to pick him up on free transfer. Apart from him being a good goalkeeper, he has the experience to play in Premier League, and he is a very good man and very liked in the dressing room and that's also a role important for the third goalkeeper.
"He's ready for it but it will always be helpful if the fans support him tomorrow."
On rookie Armin Pesci being on bench, Slot was confident.
"He's already been on the bench. Of course he's on the bench tomorrow, he's already played minutes at the top level in Hungary. He's played multiple games for under-21s and is getting better.
"Still very young, progress to be made, but we think we've signed a talented goalkeeper who could play for Liverpool in the future. If he has to come in tomorrow then I would be comfortable with that."
Alisson future
Beyond his fitness issues, this week has also seen Italian press speculation linking Alisson with Juventus.
Slot touched on the rumours, stating: "I'm only focused on short term and getting him back in goal.All these rumours that are out there about him or about me or others, we don't react to rumours in this room.
"Not in my conversations with Richard, we only react when facts need to be told and there's nothing at the moment.
"He wants to be in goal for the club he loves to play for and then the country he loves to play for."
On the Brazil international's injury issues this season, Slot insists it's been due to the heavy schedule.
He continued: "We are looking at these kind of injuries he is having. Muscle injury you always look to prevent with your training programme. He's not the only one.
"But football has changed so much, muscle injuries more and more and more and we all know why, the crazy schedule which to be fair I like as I can always watch a game on television every night, but for the health of the players it's getting more and more and more.
"Maybe age plays a part but this week we saw (Lamine) Yamal get an injury, it's more to do with the schedule they are playing.
Crystal Palace strengths
On what he expects from Palace tomorrow, Slot admits he admires the Eagles on how they've handled losing key players over the past year.
He said: "What makes it difficult are the players we face. (Marc) Guehi, (Ebere) Eze and (Michael) Olise have left, Olise at Bayern Munich making a good career for himself, but they have a good manager who has created good discipline in that team.
"Really hard to create chances against them. No matter what games I watch of them you watch 60 minutes and the other team haven't created a chance. At other end they are very direct with good attackers going quite fast.
"I think they have conceded after Arsenal the least goals and there's a reason for that."
Isak and World Cup
Slot also discussed Alexander Isak's playing return, insisting a full World Cup campaign will be good for the Sweden striker.
After missing preseason, Isak suffered a double leg fracture in December and only made his playing return this month.
While the World Cup will mean a shortened preseason this summer, Slot is positive about it's effects on Isak's preparation for next season.
"The World Cup won't hinder him," he said. "What would be the best scenario, not 100%, a very good pre-season of six weeks would have been very good lead up, but if he has a good World Cup and plays a lot of games then that will be helpful.
"Usually tempo at international level is lower than Premier League but I'm happy he is back.He has had a lot of months without training with the team. In the middle of season when everyone else is fit, it's not easy to come back, but we are seeing progress.
"I don't know when his best level will be, but I'm hoping for ourselves and him it's very soon."
Freddie needs your support
Slot also made an appeal to fans, with protests planned before kickoff at Anfield and also inside the stadium during the game. Official supporters' groups are hitting back over the board's plans to increase season ticket prices over the next three years.
In response, Slot sought to remind the support of what is at stake tomorrow.
He said: "As long as I'm in football there are disagreements and as they are alwasy about people with best interests of the club. Two weeks ago there was a protest and we had felt we had the full support of the fans.
"We will need the support of the fans. Freddie Woodman if he has to start a player like him will need a lot of support from our fans."