The defender will start alongside Victor Lindelof at Old Trafford, with fellow youngster Harry Amass also starting at left-back.
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Fredricson, 20, has come right through the United youth system and today will mark a first team debut at any level for the centre-half.
Fredricson has made matchday squads in the past for both the Premier League and Europa League.
The defender penned a first pro contract with United in 2022.
United meet Wolves at Old Trafford today sitting in 14th place on the Premier League.