The Gunners beat Ipswich Town 4-2 in the previous round and they head into this game on the back of a 2-0 home Premier League win over Everton to pull level on points with table toppers Manchester City.
Mikel Arteta is on course to make wholesale changes - based on his lineup against the Tractor Boys back in September.
Arsenal v Fleetwood team news
Among the alterations for Arteta will be a start in goal for Kepa Arrizabalaga in place of David Raya.
Martin Zubimendi and Cristhian Mosquera are in line to come in for the away side, as is Max Dowman, after the 16-year-old scored twice in that cup victory at Portman Road.
Arsenal predicted lineup v Fleetwood
Arsenal XI: Kepa; Timber, Konsa, Mosquera, Lewis-Skelly; Zubimendi, Merino, Guimaraes; Dowman, Gyokeres, Eze.
Arsenal v Fleetwood kick off time
Kick off at Highbury Stadium is set at 8pm in the UK.
Key stat
Arsenal have not won the EFL/Carabao Cup since 1993 and under Arteta's leadership thy have only reached the semi-finals - in 2022 and 2025.