Bielsa's plans for the tournament have been heavily impacted by injuries with Barcelona centre-back Araujo tearing a calf muscle just days after joining up with the squad at the start of June.
This setback continues Araujo's struggles to stay fit in the last 12 months after missing a chunk of Barcelona's 2025/26 season due to physical and mental health issues.
Atletico Madrid star Jose Maria Gimenez was fit enough to take his place on the bench for Uruguay's wild 2-2 draw with Cabo Verde, but Araujo remains on the treatment table.
Bielsa's charges have drawn both games so far in Group H - against Cabo Verde and Saudi Arabia - and they now face a huge test up against Spain on June 26 in Zapopan.
Following the tie with Cabo Verde, Bielsa offered a firm update on Araujo's recovery status, and admitted he does not know when he'll be ready to return to action.
"Neither (Giorgian) De Arrascaeta nor Araujo have a chance of playing against Spain. That's all I know right now."
Bielsa has only made one change to his backline in between those two matches - with Juan Sanabria rotating in for Matias Vina - but the veteran coach could risk Gimenez from the start against La Roja as he fights to secure a place in the knockout stages.