The Three Lions secured a perfect start to the tournament with a 4-2 win over Croatia in their opening Group L fixture and next up is the Black Stars.
Victory will put England into the knockout stages with a group game to spare and the meting with Carlos Queiroz's team will be a historical one for three members of Thomas Tuchel's squad.
Veteran campaigners Jordan Pickford, John Stones and Harry Kane all started against Croatia and the latter will captain England at the Gillette Stadium in his 116th international appearance.
That moves the Bayern Munich striker above David Beckham into third place on England's all-time appearance list with only Wayne Rooney (120) and Peter Shilton (125) ahead of him.
Kane's double against Croatia also extended his tally to 81 at the top of England's goal charts and he's now level with Gary Lineker on 10 World Cup goals scored for his country.
However, the Ghana game is also be a Beckham-themed milestone for Pickford and Stones, who will make their 14th World Cup appearance - if Stones retains his place - meaning the duo will move into joint-second for games on the world stage for England ahead of Beckham.