Chelsea were level at 2-2 after 74 minutes but collapsed in the final 16 minutes as PSG made it 5-2 in what is now a commanding lead for the champions heading into the second leg at Stamford Bridge on Tuesday.
The Blues are now reeling from a third loss in five games across all competitions following Saturday's 1-0 Premier League defeat to Newcastle United as reports claim that Liam Rosenior is close to being let go.
Rosenior will be without Levi Colwill (knee) and Filip Jorgensen (groin) in defence whilst Pedro Neto (suspended), Estevao (thigh) and Jamie Bynoe-Gittens (thigh) all miss out elsewhere on the pitch.
PSG have just two injuries in Quentin Ndjantou (hamstring) and Fabián Ruiz (knee) as Luis Enrique manages a side who are relatively injury free heading into the tie where they must defend their stunning lead.
PSG already have one foot in a quarter-final clash where they could face Galatasaray or Premier League champions Liverpool who would both be underdogs against the Ligue 1 giants.
This will be PSG’s will be their fourth visit to Stamford Bridge overall and their first in almost exactly 10 years as they aim to make history in West London.