Both Rasmus Højlund and Christian Eriksen are starting, and this means, among others, that Casemiro and Joshua Zirkzee are on the bench.
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So are Matthijs de Ligt and Lisandro Martinez. Harry Maguire and Jonny Evans start in central defence instead.
Man Utd XI: Onana; Mazraoui, Evans, Maguire, Dalot; Mainoo, Eriksen; Garnacho, Fernandes, Rashford; Hojlund.
Subs: Bayindir, Lindelöf, De Ligt, Martínez, Zirkzee, Diallo, Casemiro, Antony, Ugarte.
Aston Villa XI: Martinez; Cash, Konsa, Torres, Digne; Tielemans, Barkley; Philogene, Rogers, Bailey; Watkins.
Subs: Gauci, Carlos, Durán, Buendía, Nedeljkovic, Maatsen, Bogarde, Swinkels, Young.