The fullback thrived under former Reds manager Jurgen Klopp and O'Neill is confident things won't change with Slot.
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"There’s always uncertainty when a new manager comes in, but I think the signs for Conor have been very positive since Arne Slot came in and it’s just about trying to get as many minutes as possible," O'Neill told BBC Sport NI.
"That’s not an easy task with a squad like Liverpool have but while he has always played at right-back for Liverpool he has shown for Northern Ireland that he can be adaptable.
"We’ve played him in a different couple of positions for NI where he has shown up extremely well. I’m sure Liverpool will have taken note of that."