Atletico and Arsenal played out a 1-1 draw in the first-leg of their Champions League semifinal, with the visitors' complaints centred on Eze's late penalty claim being overturned by VAR.
Ref Danny Makkelie initially gave a penalty, but VAR intervened and requested the Dutchman make a video check on the sideline. It was there that Makkelie was confronted by Simeone, who gave his version of the episode while waving his arms angrily.
Eventually, Makkelie chose to reverse his initial decision - so infuriating Arsenal.
Keown later said: "I simply don't think it was clear and obvious. The referee should be able to referee the game. The VAR has got too involved. It is not what we wanted with VAR, it's not part of the protocol really.
"Simeone though, his actions on the sidelines... the drama that he creates and the scenes around it... the referee in the end I thought buckled under the pressure, went to the screen and didn't stand by his decision. I don't think he should have even been made to go to the screen."
He added: "You need to keep your decorum after a game, and I don't want to go too far with it, but something was very wrong there tonight. He orchestrates the crowd here but he orchestrates the officials too. He creates a drama."