Just as Vazquez was leaving Real for Bayer, Xabi was moving in the opposite direction to succeed Carlos Ancelotti as Real Madrid coach.
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However, Xabi's first six months in charge haven't gone to plan and his position is in sharp focus during LaLiga's Christmas break.
But Vazquez told AS: "It happens all the time, it's certainly nothing new.
"I'm convinced he can do it. I think he'll have a great season and do an excellent job at Real Madrid.
"He deserved this opportunity. He proved himself to be a great coach in Germany, and I'm sure he'll be able to prove it in Madrid as well."