Ahead of Sunday's trip to Getafe, Pellegrini says Isco and Giovani Lo Celso are due to return after this month's international break.
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Isco is recovering from an ankle injury, while Lo Celsco has thigh strain.
Pellegrini was asked for an update this morning and said: "Isco has also been progressing quite well in his recovery. He might not be available before the break, we'll see if he can rejoin the group training sessions.
"Once he rejoins the group, it always takes one or two weeks to recover. I don't think either he or Gio will be ready before the break."