The defending Spanish champions have won all six league games played so far in the new campaign plus an opening victory in the UEFA Champions League against Feyenoord.
Flick wants to go into international break with an unbroken record and his side hammered Racing Santander 7-2 in midweek.
Barcelona v Sevilla team news
Joan Garcia was forced off at half-time in the win over Racing Santander and Flick confirmed he will miss this game and Spain's incoming Nations League matches.
Wojciech Szczesny replaced him at the break, and despite a nervy showing, Flick will keep faith with the veteran Polish stopper as a stand-in.
Frenkie de Jong won't be back until after the international break and Roony Bardghji is out for the season after suffering an AC tear.
Barcelona predicted line up v Sevilla
Barcelona XI: Szczesny; Kounde, Cubarsi, Martin, Cancelo; Rodri, Pedri, Olmo; Lamine Yamal, Raphinha, Gordon.
Barcelona v Sevilla kick off time
Kick off at the Estadio Ramón Sánchez Pizjuán is set for 9pm local time and 8pm in the UK.
Key stat
Barcelona simply can't stop scoring goals this season and Flick's team have bagged five or more in their seven domestic and European outings.