Tuchel started with a backline of John Stones, Marc Guehi, Ezri Konsa and Nico O’Reilly at the back for England’s opening 4-2 win over Croatia in a decision that worked out.
The Three Lions are top of Group L and a win against Ghana in their next clash would see them book their place in the next round alongside Mexico who also won both their opening clashes.
Four-time AFCON champions Ghana will not an easy opponent however and Neville has called for Tuchel to take precautions as he expects a much more likely attack from the African giants.
"I do expect changes. Ghana have got Antoine Semenyo, they’ve got Brandon Thomas-Asante, they’ve got players who can play one-vs-one, who are mobile. So I do think Guehi coming in makes sense, and maybe Djed Spence as well.
"I thought Spence was excellent when he came on against Croatia. I don’t think John Stones will play every single game, every three or four days.
"Stones has got very good experience and I think there will be a place for him at the tournament, and there was last night, but I do think we could see Guehi come in, being someone who can handle one-vs-one situations a little bit more and the physicality of the running of the Ghanaians.
"I think Spence is someone again who will play a big part in this tournament, whether it’s right-back or left-back, because I think he’s like a leech when he defends. He’s very aggressive in his work and he’s got a great tenacity about him."
This will be only the second meeting between England and Ghana with the first coming back in March 2011 in a friendly at Wembley, which finished 1-1.