The 19-year-old missed the 2-0 midweek win in Czechia due to a knee problem, but Luis de la Fuente has confirmed he's fit to take on England in Madrid, alongside the returning Mikel Oyarzabal.
Both players should start in a reshuffled La Roja attack at the Estadio Metropolitano and Lamine Yamal has been handed a new squad number for the game.
He traditionally wears No.19 for Spain - his old number at Barcelona - but against Thomas Tuchel's team he'll switch to the No.10 he now wears for his club.
The reason being Dani Olmo's injury and absence from the current camp and he'll replace Victor Munoz - who donned the number in Prague.
For Spain, squad numbers are chosen based on seniority and number of international appearances, and Olmo will reclaim it when he returns in 2027.