The former Aston Villa prospect is enjoying career best form this season in Serie A with the Zebrette.
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And De Canio told Messaggero Veneto: "Ready for a top club? Yes, on a technical level, because Davis knows how to play football.
"But the question mark remains linked to his reliability, which is put into doubt by injuries, as with (Nicolo) Zaniolo and this is the only handicap for an attacking duo that I consider among the strongest in the league in terms of technique and physicality."
On Udinese this season, De Canio added: "Udinese's performance is inconsistent, penalized, I believe, by the injuries that have gradually sidelined their key players, especially Zaniolo."