Lautaro, after drawing two consecutive blanks, struck twice in victory at Pisa on Sunday.
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Cassano said on Viva el Futebol: "This guy hasn't been on holiday for four years, and I say that to the incompetent people who criticized him.
"He's always full of blood, he has a huge personality: he's a fantastic player, by far the best striker in Serie A and among the best in the world. I'm crazy about him.
"Sometimes he makes a mistake in the game, so what? He's making history with Inter, you can't touch him because of his attitude.
"If he plays until he's 35 or 36, he could become the Nerazzurri's all-time top scorer, and I'd be happy because he's a guy who deserves it. I like him because he has extraordinary quality."