The former PSG goalkeeper will make his full City debut at the Etihad - as will Benjamin Sesko for Manchester United.
Sesko will make his first start for United in the absence of Matheus Cunha.
For City, local boy Phil Foden also starts with Ruben Dias, Josko Gvardiol, Nico O'Reilly and Jeremy Doku coming in.
Matheus Nunes and Oscar Bobb drop to the bench, while John Stones, Rayan Ait-Nouri and Omar Marmoush are not involved.
Manchester United manager Ruben Amorim has gone with Altay Bayindir as his goalkeeper despite Senne Lammens arriving from Royal Antwerp for £18m on deadline day.
Line-ups:
Man City XI: Donnarumma, Khusanov, Dias, Gvardiol, O'Reilly, Rodri, Reijnders, Silva, Doku, Foden, Haaland
Man Utd XI: Bayindir, Mazraoui, Yoro, De Ligt, Shaw, Dorgu, Ugarte, Fernandes, Diallo, Mbeumo, Sesko