The sides could not be separated after 90 minutes at the Etihad Stadium as Geronimo Rulli's spot kick heroics eventually nudged the hosts into the quarter finals.
It's back to the Premier League day job in Manchester and both Maresca and Fabian Hurzeler will make significant changes to their starting lineups.
Man City v Brighton team news
Maresca has confirmed Antoine Semenyo is the only member of his squad unavailable for this game as he remains out with a knee issue.
Gianluigi Donnarumma, Elliott Anderson and Erling Haaland will be among those players recalled for the home team as City look to extend their lead at the top of the table with a positive result.
Man City predicted lineup v Brighton
Man City XI: Donnarumma; Nunes, Dias, Guehi, Gvardiol; Anderson, Fernandez, Cherki; Foden, Haaland, Doku.
Man City v Brighton kick off time
Kick off at the Etihad Stadium is set at 3pm in the UK.
Key stat
Defeat in midweek was the first time Hurzeler has lost to City as Brighton boss with two wins and two draws from four Premier League meetings.