During the 1-1 draw with Uruguay at Wembley, starter Madueke was forced off on 38 minutes.
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After being clattered by Rodrigo Aguirre, Madueke underwent treatment and tried to shake off the knock but eventually was substituted five minutes later.
It's unclear the extent of the injury, but Madueke seemed to be holding his face as he made his way off the pitch.
At the beginning of international week, Arsenal players Eberechi Eze, Leandro Trossard, Gabriel, William Saliba, Jurrien Timber and Martin Odegaard were all ruled out of their countries' squads due to injury.
