The £125m signing saw action with Sweden in midweek and Slot intimated Isak would play at Turf Moor on Sunday.
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However, Isak is out of Liverpool's squad for today's clash.
Former Everton captain Leon Osman reacted, stating: "It doesn't surprise me.
"I don't think he was signed to take part in this particular game - there is a long term plan to get the best out of Alexander Isak."