Isak was visibly upset as he was forced from the pitch during Saturday's win at Tottenham.
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After knee damage was ruled out, the Daily Mail says Liverpool management now believe Isak has suffered a fracture to his lower left leg.
Scans on Sunday ruled out any ligament issues for the Swede, however it's now claimed a fracture has been discovered.
The £125m striker now faces a lengthy period of recovery, with a statement due from the club,