Sesko, 22, who joined United in a £73.7M move from RB Leipzig in the summer, made his first Premier League start at the Etihad Stadium but struggled to make an impact under manager Ruben Amorim whose job is under threat.
The young striker had just 20 touches of the ball, none of which were in the penalty area. His performance caught the eye of Ferdinand who spoke on on his Rio Ferdinand Presents podcast about how Amorim should be helping him earn better chances to score on the pitch.
"The one I'm worried about is Sesko. He ain't getting no chances man, he ain't getting no opportunities, there's nothing created for him.
"That's the concern. A new striker comes in the football club, gets in the team, you've got to think about creating chances for him. Getting him on the end of things. He's got to think about getting on the end of things.
"That's something I think has got to be looked at, and fixed quick. I don't want to think about what it could turn out to be."
Despite making five appearances so far for Manchester United, Sesko is yet to register a goal for his new side. Many have blamed Amorim for his lack of chances and United’s poor tactics, which have made many of their exciting new signings look mediocre.