Leeds host City at Elland Road having lost only twice in their past 14 games.
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Farke said: "We're looking forward to this game. We're facing the best and most successful side in the UK and world football over the last decade. They've won everything.
"It's a challenge we're looking forward to. It's always great to play at a packed Elland Road.
"We are of course the underdog, but we've shown several times that we can deliver convincing performances.
"We've worked so hard to be able to play against the top sides so we value being capable of being competitive with the best teams in the world."