Salah leaves Liverpool this summer after nine years with the club and having broken more records than anyother player in the club's history.
Klopp said on Peter Crouch's podcast: "Maybe other people said it in the past when they counted the goals of Ian (Rush) or someone like that but I don't think something like (Salah's career) will happen again.
"The combination of all the things he has plus the character he is and the desire he has. I never saw someone like him. If you saw Mo in training you would think he is a very talented boy, left foot, speed, wow, great. And he starts scoring because he was not happy with his finishing in Rome, so he built a goal in the backyard.
"I am sure a lot of people built a goal in the garden and tried to improve. He did that seven hours a day in my imagination. Every summer he came back from a summer break and had a new skill, a new idea."
Klopp added: "Remember last season when we became champions, how many goals he set up, the way he set it up, cutting inside when he usually shoots, Cody Gakpo or whoever arriving, we had these situations, but he took it perfection.
"He always came with something new, he never stopped and he will not stop. He is 33 and he has another five or six years, 100%."