The 23-year-old was replaced at half-time by Bukayo Saka at the Emirates during the clash with Manchester City, which ended 1-1 thanks to a late Gabriel Martinelli goal.
Arteta pulled off the winger who featured for the first time on Sunday since the 5-0 win against Leeds United and has been impressive so far for the Gunners.
Now, he will be spending the next few months on the sidelines as confirmed by journalist David Ornstein in what is a crushing blow for the North London side.
“Noni Madueke expected to be sidelined for around 2 months with knee injury. 23yo winger sustained problem in 1st half of #AFC vs #MCFC on Sunday but understood to have avoided anterior cruciate ligament (ACL) damage.”
This means he will likely be unavailable until mid-November at the earliest and reports claim that 15-year-old Max Dowman will be handed more of an opportunity by Arteta who has a lot of faith in the teenager.
Madueke joins Kai Havertz, Bukayo Saka, Marin Odegaard and William Saliba in a vast group of players who have suffered injuries in the opening half of the season.