Two goals from Kylian Mbappe did the damage for Los Blancos as Jose Mourinho ended Barcelona's 100% start to their league title defence on a chaotic night in Catalonia.
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Cubarsi's backline struggled to cope with the pace and directness of Real Madrid's attack, but he was in no mood for excuses, after a fifth game in 15 days since returning from the international break.
"I don't want to use this as an excuse, but the schedule has been extremely packed. We've had a lot of matches and played a lot of minutes.
"It's natural to feel some fatigue, but we can't use that to justify the defeat."
Up next for Barcelona is a league home tie up against Alaves on October 31st.