The Londoners secured their spot in the European final on Thursday with a 2-0 win over Bodo/Glimt, advancing with a 5-1 aggregate victory in the semi-final.
It's been over 40 years since Spurs last claimed a continental trophy, and the defender insists they must remain fearless to bring the title back to London.
"Everybody goes to Bilbao to win a trophy. It has been a tough season and it will only be successful if we win the Europa League and get the trophy," said Van de Ven.
"United played Athletic Club, a really good team, and it was 7-1 over the two games. So they've also showed some real quality in Europe.
"We know it's going to be a different game, everything can happen in a final. But we're not going there with fear, of course.
"We know our qualities, we know it's going to be a difficult game, Man United showed their quality in this European campaign."