The English winger came on from the bench in a 3-2 win over Newcastle United in the Premier League.
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But the 26-year-old was being goaded by a fan pregame, which did not go down too well.
Rashford appeared furious in fan footage, only for other members of the team to hold him back.
Many in the crowd also yelled against the heckler and in support of the United no.10.