The 28-year-old midfielder returns to Japan after two seasons with the Potters.
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Seko made 75 appearances for Stoke following his 2024 move from Kawasaki Frontale.
“Tatsuki is a really good character, who has been an excellent professional throughout his time at the club,” Sporting Director Jonathan Walters said.
“Tatsuki and his family were open to exploring a return home and, after we reached an agreement with Urawa, he leaves with our gratitude for his commitment as a Stoke City player and very best wishes for his next chapter.”
