Rashford, who was United's top scorer in 2022/2023, has endured a miserable 2023/2024 season.
These are, of course, difficult calls," said Southgate of the omission of Rashford and former Liverpool captain Jordan Henderson.
You are talking about players that are very good players and who have been an important part of what we have done over a number of years. With Marcus, I just feel that other players in that area have had better seasons. It is as simple as that.
Hendo has given himself every chance. The determining factor is the injury he picked up around the last camp. He has missed five weeks and just hasn't been able to get to the intensity in the games since then.
Look, he is a fantastic professional. That was a really difficult call to make because has been so important, so supportive in my time here.
And I have to say all the boys, when I have spoken to them, Ben (Chiwell), Marcus, Jordan - who were the three that were with us last time - they were incredibly professional. Considering the disappointment, they dealt with it very well."