The Three Lions secured top spot in Group L via a 2-0 win over Panama, thanks to second-half goals from Jude Bellingham and captain Harry Kane, and Tuchel has made three changes from that starting XI.
Jarrell Quansah was forced off injured against Panama, and with Reece James still sidelined, Djed Spence comes in for his second start of the competition.
The Spurs defender started at left-back in the 0-0 draw with Ghana, but he'll come in at right-back this time, with Declan Rice passed fit to replace Morgan Rogers in midfield after a minor calf strain.
The big surprise in Tuchel's team is a switch between Arsenal teammates Bukayo Saka and Noni Madueke with the latter back in from the start.
Madueke was unconvincing in starts against Croatia and Panama, as the returning Saka assisted Bellingham's opener last time out, but Tuchel is opting for caution over his fitness for the rest of thee tournament.
DR Congo make just one personnel change, as Ngal'ayel Mukau comes in for Cedric Bakambu, and the African side switch to a 4-3-3 system on their return to Atlanta.