The 54-year-old Argentine, who favours a high-pressing, attacking style of play, took over the U.S. side in 2024 after parting ways with Chelsea earlier that year, and had a contract that ran through the 2026 World Cup.
"Mauricio and his staff believe in the future of soccer in the United States and our new project allows us to build on progress of the USMNT and the momentum of U.S. Soccer,” U.S. Soccer CEO JT Batson said in a press release.
Under Pochettino's leadership, the U.S. finished first in their World Cup group ahead of Australia, Paraguay and Turkey, and the six points they collected were the highest-ever total for the men's team at the tournament.
Pochettino's charges then beat Bosnia in the last 32 before losing 4-1 to Belgium in a disappointing end to the campaign for a side were hoping to make a deep run on home soil.
"Working together with U.S. Soccer over the past two years, it has become clear to us that there is tremendous potential to make the Men’s National Team program even stronger,” said Pochettino.
“The passion we experienced from the fans throughout the World Cup only strengthened our belief in what is possible here."
The former Argentina defender guided Southampton to an eighth-place finish in the Premier League in 2013 - the club's highest-ever finish at the time.
He went on to lead Tottenham Hotspur to a first Champions League final appearance in 2019 and in 2022 steered Paris St Germain to the Ligue 1 title.
Pochettino left Chelsea by mutual consent in 2024 after a turbulent campaign despite a late rally to a sixth-placed finish.