The Three Lions survived a Round of 32 scare to beat DR Congo 2-1 in Atlanta and a trip to the Estado Azteca is their first game of the tournament to be played outside the USA.
Adjusting to an increase in temperature is one area of concern for Thomas Tuchel and his players alongside concerns over several injuries in key squad areas.
Tuchel has insisted there's insufficient time to prepare for the altitude increase - with Mexico's main base is around 7,200ft above sea level which can make the air thinner and mean less oxygen is absorbed in the bloodstream as a significant barrier to player performance.
The lack of time in between games is a concern, with just five days from the DR Congo clash to facing Javier Aguirre's team, and a leading expert has claimed England will have little choice but to change their approach.
"Maximum aerobic capacity at this kind of altitude usually drops around 10%, and that has a knock-on to performance," Dr. Barney Wainwright, senior research fellow at Leeds Beckett University, told BBC Sport.
"There will usually be a 15-20% increase in fatigue. For the distance it's possible to cover, we would expect that to drop by 5-10%.
"Maximum sprint speeds won't be affected, but players will need to wait a bit longer to recover from each one and go again
"England might want to slow things down more to allow the players time to recover between bouts of high intensity play."