The 27-year-old was shown a straight red card for a rash challenge on United forward Bryan Mbeumo just four minutes after kick-off at Old Trafford.
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Mbeumo was one-on-one with Sanchez, who decided to completely take out the Cameroon international, leaving the referee with no choice.
Chelsea manager Enzo Maresca then decided to take of wingers Pedro Neto and Estevao, replacing them with Filip Jorgensen and Tosin Adarabioyo.