Arsenal defender Ben White opened the scoring on his England recall, though conceded a late penalty, which was converted Real Madrid midfielder Fede Valverde for Uruguay.
Tuchel said afterwards: "It was not a penalty.
"To sum it up I think our goal was also a block, tough block from Wharton, but they checked it and gave it.
"Absolutely OK with the performance. We tried and tried and were the better team overall.
"We had some big chances from set-pieces. We were forced into changes. We had a lot of new players and changed a lot of new players and for all of that I am grateful for the test.
"I have to review it, I liked how we played. We knew it was a difficult opponent. Marcelo Bielsa told me months ago he would arrive with his best team. Everyone did good. I liked a lot of stuff today."
On White, he said: "It was too good to be true when he scored the winner which in the end was not a winner. In the end he was perhaps too greedy in his defensive actions but it was not a penalty."
On whether he hopes White's goal might help change some views, Tuchel added: "I hope so. This happened before to some players here which is disappointing because I don't think it helps anyone. There was a mixed reaction."