The third-placed Red Devils hold a three-point advantage over the fourth-placed Reds in the Premier League table as they welcome their biggest rivals to Old Trafford.
All three points could secure Liverpool’s place in next season's Champions League, Arne Slot’s main goal after losing out on the title and being knocked out of every other competition.
United have only won two of their last 15 Premier League games with Liverpool who are without a number of stars ahead of the clash which will be a huge worry for supporters.
In defence, Slot will have to cope without Milos Kerkez (Other), Alisson Becker (Other), Giorgi Mamardashvili (Knee Injury), Giovanni Leoni (Knee Injury) and Conor Bradley (Knee Injury).
Further up the pitch the likes of Hugo Ekitike (Calf/Shin/Heel Injury), Wataru Endo (Ankle/Foot Injury) and Mohamed Salah (Thigh Injury) are all out in what will be a bare-bones Liverpool side.
In this clash, Liverpool have enjoyed the better of the recent league meetings, triumphing in six of the last 12 match-ups in England's top flight, with just two defeats in the process.
Liverpool are also sweating over the fitness of Alisson who is just one of many players including Salah, Andrew Robertson and Curtis Jones who could depart this summer in what is a huge clear out for Slot’s side who simply haven’t been good enough this season.