Across the last 10 meetings between these sides, United have five wins, Brentford have three, with two draws as the Red Devils tend to dominate this fixture.
Michael Carrick’s side are third in the Premier League table, eight points ahead of sixth-placed Brighton & Hove Albion with a game in hand as they chase down Champions League football.
United will welcome defender Harry Maguire back after he missed the loss to Leeds and the win over Chelsea through suspension.
However, they will still be without fellow defenders Matthijs de Ligt (Lower Back Injury), Lisandro Martinez (Suspended), Patrick Dorgu Larsson (Thigh Injury), Leny Yoro (Other).
United will face Liverpool, Sunderland, Nottingham Forest and Brighton in their final four league games of the season and will aim for maximum points under Carrick who will surely get the job permanently if he takes the side back to Europe’s top competition.
However, United have lost their last two matches against Brentford and will have to be cautious as the Bees have drawn each of their last five Premier League matches as they continue to take points from top sides.
Brentford will aim to beat Man United away from home in the Premier League for the first time and with Liverpool hot on the heels of Carrick’s side, they will need to be at their best to collect all 3 points.