According to The Sun, Yoro, 20, was absent as Man United boarded the train down to London ahead of their game at Stamford Bridge.
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The report adds that the club are worried that Yoro’s season might be over as we enter the final few weeks.
Michael Carrick’s defensive options are sparce, with Lisandro Martinez and Harry Maguire both suspended.
Matthijs de Ligt is also out due to his back injury, meaning Ayden Heaven is United’s only available natural centre-back.