Wenger insists Slot has "destroyed" Liverpool's title winning midfield to fit in the £125m arrival.
"Everyone has a right to his own opinion and many of them have," said Slot on Friday. "That is the nice thing about football, that everyone has his opinion about it.
"If I need open-heart surgery, I am not going to tell the surgeon what he needs to do but about football everyone is telling you what the best thing is to do but that that is also the nice thing about football because everyone knows it so we can talk about it.
"I think we have five or six very good midfielders who can all play together but they need to play more together to get the best out of every single player. Florian, he needs time to adapt to his teammates, team-mates need time to adapt to him.
"But he now played off the left. But I can tell you if it is not this season it is the other season or if it is not now it is tomorrow, he will have great performances as a midfielder for Liverpool as well. There has been a lot of focus on him individually and I'm more focused on team performance."