The fit-again Swede, who has an excellent record in derbies, could start on the day.
Isak hasbeen on the scoresheet in derbies for former clubs Newcastle United, Real Sociedad and AIK.
He told liverpoolfc.com: "I don't really know my record in those games! But I think those are the games that mean the most for the fans and for the players.
"It's those moments and those games we want to play, and hopefully we can make a good day out of it.
"I think we just need to do a good performance, work hard and play as a team. The quality is there, so we just need to show it."
Isak is back after suffering a double leg fracture before Christmas.
"Obviously I was out for a long time and I've been working hard to get back," Isak said. "Very happy to be back out there.
"It's never easy being out for a long time. But I feel like I'm getting there and hopefully we can get the results as well."