Strikers Wissa and Nick Woltemade started on the bench, though only Woltemade was thrown on by Howe in the second-half.
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The Toon manager said after the 2-1 defeat: "Of course, we try to make every player work regardless of the name or the individual.
"I want ever player to feel part of what we’re doing and feel they’ve got an opportunity to play.
"But there is a big demand on Nick when he comes on to the pitch that he has to perform – I thought he did okay today.
"But I can only pick, with the system that I play currently, one striker and that at the moment is Will (Osula), and I think he’s justified that in the two games, so I can’t play everybody as much as I’d like to."