The Blues lost 2-1 on Sunday night, with Pedro Neto seeing red.
James said afterwards: "It's disappointing to walk away empty handed. When it was 1-1 we had a half chance to make it 2-1, their goalie made a good save, they got a set-piece and manage to score."
Both Arsenal goals came from corners and James continued: "This is football now in 2026, 90% of goals are probably set piece. They (Arsenal) are one of the leaders in the world (at set-pieces).
"They are difficult to stop, they scored two today. Disappointed. But we scored one, we had another chance to score another but it wasn't meant to be today."
On Chelsea's disciplinary issues, he concluded: "We've spoken about it, it's come up a number of times, every time it's someone different, not the same player. Internally we need to review and keep improving. It's a problem, we are playing in the toughest league in the world, you play against top or bottom 11 v 11 it's tough, 11 v 10 is even harder no matter who you are playing.
"I have no doubt in the team and staff, it didn't go our way today but we need to regroup and go again."